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Indonesia is a country rich in flora and fauna. One of the plants that are being developed to become herbal medicinal plants is the gambier plant. This plant is spread in Aceh, North Sumatra, Riau, West Sumatra, Bangka, Belitung, and West Kalimantan. In West Sumatra this plant spreads throughout the region, such as in 50-kota, Pesisir Selatan, Tanah Datar, Pariaman, Sawahlunto, Pasaman and Solok.1

The Impact of Sub Acute Administration of Purified Gambier (Uncaria gambir Roxb.) to The Liver and Kidney Functions and its Reversibility on Rats