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Lung cancer is the world's leading cause of death and it has been noted that 7.6 million deaths were recorded in 2008. Death rates have been forecast to rise by more than 11 million in 20301. Usually, 80 percent of cases of histologically non-small cell lung cancer are a big health issue2. Due to the high incidence rate, rapid development and poor prognosis, lung cancer-related deaths have been the leading cause3. With an average survival rate of around 15 percent, it has become a burden worldwide4. There are more medications available today to manage lung cancer. Chemotherapy is the routine treatment for lung cancer, but it does have several side effects that also affect the quality of life of patients5. It is still deficient, considering the numerous treatment methods available to avoid these side effects6,7. Therefore, new drugs or innovative ways to cure or avoid this global warming disease are being pursued. Several medicinal plants have been used globally for the treatment of different forms of cancer 8. Conventional medicine with its low toxicity and side effects has the ability to treat anticancer activity. According to the WHO study, in contrast to modern medicine, 80 % of the world 's population relies on conventional medicine because of its less side effects, cost effectiveness, protection, and effective prognosis9. Even today, several tribal groups are practicing herbal medicine to cure various diseases10. The medicinal plant belonging to the Vitaceae family is Cayratia auriculata. Cayratia auriculata (Roxb.) gamble is a synonym for Cyphostemma auriculatum (Roxb), a climber well cultivated in dry evergreen to dry deciduous forests and well distributed in Andhra Pradesh, Tamilnadu, and Maharashtra11,12. For several diseases, cayratia auriculata has been used as herbal medicine. The leaf is the most important part of the plant as it has potent ethno-medicinal properties. It is used in the treatment of snake bite, dog bite, abscess, rheumatism, cardiovascular disease, tumours, and also in the treatment of cold, cough, worm infestation13. The genus is also used for bloody dysentery and diarrhoea in veterinary medicine. Based on previous studies, a study on the cytotoxic activity of C. auriculata extract is still limited to lung cancer. The present study was therefore conducted to determine the anticancer and cytotoxicity potential of Cayratia auriculata unrefined ethanolic leaf extract.

Anti-Cancer Activity of Cayratia Auriculata Ethanolic Extracts Against Cancer Cell Line A549 An In Vitro Analysis