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Agaricus blazeii Murill is a low-level plant which is a functional food and has the potential to have activities both in vitro and in vivo, including reducing blood sugar, lowering blood pressure, reducing cholesterol, reducing arteriosclerosis1-11, antioxidant, antiviral, antimutagenic, anticarcinogenic.7,12-19 Other names for Agaricus blazei Murill are A.subrufescens, A.sylvaticus, and A.brasiliensis13. Several studies have been carrying out related to the activity of the extract as an anticancer, namely research on 50% ethanol extract of Agaricus blazei Murill that can inhibit the growth of Hela cells with an IC50 value of 194.4 μg / mL.17 Agaricus blazei Muril extract can also inhibit myolema cells and leukemia cells20-24. Agaritin isolates from Agaricus blazei Murill can also inhibit the proliferation of leukemia cancer cells U937, MOLT4, HL-60, and K-562 with IC50 values of 2.7; 9.4; 13.0; and 16.0 μg/ mL1. Blazein isolate from Agaricus blazei Murill extract can also induce the death of human lung LU99 and stomach KATO III cancer line at a concentration of 200 μg /mL.25,26 Polysaccharides obtained from the isolation process of Agaricus blazei Murill extract have the potential to inhibit osteosarcoma cell proliferation (HOS cell line) at a concentration of 100 μg/ mL. Agaricus blazei Murill extract can inhibit proliferation in DU145 and PC3 prostate cancer cells 400 μg/ mL and 800 μg/ mL.27 Hot water extract of Agaricus blazei Murill also inhibits the growth of pancreatic cells.16

Ergosterol Isolated from Agaricus blazei Murill N-Hexane Extracts as Potential Anticancer MCF-7 Activity