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There is comprehensive experimental and clinical sign that several aspects of the behavioural, endocrine and immune systems are severely compromised following exposure to chronic stress.1 The stress effects appear to be determined by the duration rather than the intensity of the external or internal stressful stimuli. Thus, acute and transient stress, of a severe nature, may be less harmful than mild stress continued over a length of time.2 Additional main aspect, which initiates and exacerbates stressinduced effects, is the failure of the body to cope with the stress condition. The introduction of the factor of unpredictability makes it difficult for the individual to adapt, and therefore cope, to the stressor.3 Stress has been hypothesised that a variety of diseased states induced their involvement of etiopathogenesis, ranging from psychiatric disorders like anxiety and depression, endocrine disorders including diabetes mellitus, male impotency, and cognitive dysfunctions, to diseases like hypertension, ulcerative colitis and peptic ulcer.4 Therapy of stress includes an alternative system of medicine, allopathic which is being currently available, but allopathic medicine drugs especially benzodiazepines category is having a various adverse effects (side effect, tolerance, and dependence) which limit its uses. Thus herbal formulation needs for management of stress on long term use.5 Rasayanas of Ayurveda are effective adaptogenic agents because they seem to prolong, Selye’s proposed stage of the “General adaptation syndrome”, the stage of resistance to stress, and prevent the final and third stage of exhaustion.6

Beneficial Effects of Sambucus nigra in Chronic Stress-Induced Neurobehavioral and Biochemical Perturbation in Rodents