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Endothelial dysfunction is a pathogenic factor of many diseases such as diabetes, arthritis, and hypercholesterolemia.1-3 Endothelial cell dysfunction also contributes to cardiovascular disease development like atherosclerosis, hypertension, myocardial infarction, and stroke.4-6 Major contributor for endothelial dysfunction is Nitric oxide (NO) bioavailability decreasing. Normally, NO is produced trough converting L-arginine catalyzed by NOS.6,7 NO is a potent vasodilator and essential regulator for vascular tone and blood pressure.8 NO also plays a role in regulating hemostasis, and leukocyte adhesion and smooth muscle cell proliferation.6

pharmacognosy journal

Arginase Inhibitory, Antioxidant Activity, Total Phenolic Content and Total Flavonoid Content of Ethyl Acetate Extract of Caesalpiniaturtuosa Roxb Stem Bark