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There are some reports about the interaction between saffron and opioid system.1,2 Studies have shown that saffron and its constituents can alleviate morphine-induced behavioral disorders. Meanwhile, in different geographical regions, the saffron extract has been proven to reduce the withdrawal signs in morphine-dependent mice.2 However, despite the undeniable effect of geographical and climatic conditions on the quality of the plant’s impact,3 there is no evidence of the effect of Afghan native saffron on morphine withdrawal signs. This study aimed to evaluate the effect of aqueous extract of Afghan native saffron on withdrawal signs in morphine-dependent rats, using the behavioral method.

Effect of Afghan Saffron (Crocus sativus L.) Aqueous Extract on Withdrawal Signs in Morphine-Dependent Rats