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Hypertension is a major public health problem. According to the World Health Organization1, an uncontrolled rise in blood pressure may predispose a patient to a heart attack which will eventually lead to heart and kidney failures, stroke, and cognitive impairment. It was estimated that the worldwide prevalence of hypertension exceeded 1.3 billion, representing 31 % of all adults.2 Throughout the years, the condition of raised blood pressure among the hypertensive patients was uncontrolled.3 While there are available antihypertensive drugs in the market, the global condition remains stagnant since the treatment is expensive, thus an average or a poor society did not afford to receive the best treatment regime. In addition, the concomitant drugs’ side effects such as dizziness, abnormal heart rate, sore throat, sexual dysfunction, thrombocytopenia, and hyperglycemia4 are undesirable, and this untoward reaction actually occurs more easily when drugs are used in combination.5 The expensive cost and the side effects of the currentlyavailable antihypertensive drugs have enforced the research for new alternative antihypertensive drugs which should be at least equally effective, but yet inexpensive.

Antihypertensive Assay-Guided Fractionation of Syzygium polyanthum Leaves and Phenolics Profile Analysis Using LCQTOF/ MS