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The increasing incidence of diseases is a huge burden on any country, which needs to be addressed in a priority basis to reduce the incidences, morbidity and mortality. Alternative medicines and treatment based on natural products have gained a role in health management over the last few years. Natural products or various compounds of medicinal plants play an important role in the management of diseases including cure and inhibition through modulating various biological activities. Treatments based on natural products have been demonstrated to play a significant role in curing diseases without any adverse effect on the body and physiological process. Moreover, alternative medicines and natural products derived from a variety of sources are safe, inexpensive and also do not show any adverse effect on cell signalling pathways and biological cascades. In this regard, garlic and its active compounds have shown a potential tendency to cure many diseases t. Garlic and its active compounds such as allicin, ajoene, diallyl sulfide (DAS), diallyl disulfide (DADS), s-allyl cysteine and, diallyl trisulfide (DATS) (Figure 1) show a potent role in modulating the various cell signalling pathways. In this review, we discussed laboratory based experiment of the role of garlic in management of diseases through modulating various biological activities. 1-7 Besides, we discussed different strategies that improve the therapeutic efficiency of drugs, bioavailability, absorption and metabolism of garlic active compounds.

Garlic and its Active Compounds: A Novel Strategy to Fight Diseases Through Modulating Biological Activities