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Memory loss is a common phenomenon and remains a challenge in management of several neurological diseases like epilepsy, Alzheimer’s, neuro-degenerative, neuro-metabolic, vascular disorders of central nervous system and in psychosomatic disorders. People suffer from several age related physiological disorders including learning and memory loss. The incidence, prevalence, morbidity, mortality and burden of disease have become increasingly relevant to the practice of clinical public health and health policy.1,2 SWRT is an Ayurvedic formulation prescribed for acute anxiety, fatigue, insomnia, partial loss of memory and low grasping power.3 This herbal brain tonic is also prescribed for slurred speech, dementia, certain neuro degenerative diseases and several other physiological disorders. In consonance with previous studies, in which Saraswatha choorna (the powder form of Saraswatharishtam) was reported to have antidepressant and anti-anxiety roles, the present study was conducted. Some reports on the anti-amnesic roles of plant derived medicines as compared to piracetam on scopolamine induced memory loss in animal models are available.4 Scopolamine is a centrally acting muscarinic cholinergic antagonist used in animal experiments to induce memory impairment.5,6 Scopolamine is commonly used as model for characterization of potential cognition enhancing drugs. Recently several studies reported that Scopolamine induced memory impairment in animal model is closely associated with the brain.7-10 Piracetam comes under smart drugs used for neuro-protection on experimental animals since last three decades.11,12 This drug plays a critical role in enhancing acetylcholine function through muscarinic cholinergic receptors and these receptors play a vital role in memory and learning. Piracetam enhances cell membrane permeability and increase oxygen consumption.

Neuro-protective Effect of Ayurveda Formulation, Saraswatharishtam, on Scopolamine Induced Memory Impairment in Animal Model