English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Pulmonary fibrosis is a condition of scar tissue formation that involves infiltration of inflammatory cells, fibroblasts proliferation, reactive oxygen species (ROS), and excessive accumulation of extracellular matrices to the pulmonary parenchymal tissues and can cause dysfunction to pulmonary function.1,2 The appropriate treatment for pulmonary fibrosis is still a challenge. The use of chemical substances effective for pulmonary fibrosis treatment does not always provide consistent significant results due to adverse events.3 Several methods to prevent and reduce pulmonary fibrosis have been widely conducted using drugs that interact with TGFβ and have the potential to activate anti-fibrosis. The drugs were tranilast (inhibit the activity and secretion of TGFβ), losartan (TGFβ induction blockade), PPAR-y agonists (damaging Smad3 signal transduction), pirfenidone (inhibit the production of TGFβ), and halofuginone).3 The effectivity limitations of these chemical substances in overcoming pulmonary fibrosis lead to the utilization of natural ingredients as an alternative.

In vitro Assay and Study Interaction of Uncaria gambir (Hunter) Roxb. as Anti-fibrotic Activity Against A549 Cell Line