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Liver is the second largest and vital organ in the body which plays a vital role in metabolism and maintenance of homeostasis in human system. Toxic liver injury produced by drugs and chemicals are similar to natural liver disease. Continuous use of agents like Rifampicin, Isoniazid, Paracetamol, Ethyl alcohol, Carbon tetrachloride, Ranitidine and Oral contraceptives of hormonal origin and chemicals used as food preservatives and agrochemicals are threatening the integrity of liver.1,2 The effects of liver disease on hepatic metabolism of drugs are complex and difficult to predict, particularly when multiple drugs are administered simultaneously.3 Undiscerning use of anti-malarial drugs4, Anti-tubercular drugs5, analgesics, oral contraceptives6, Pharmaceuticals (mainly antibiotics, chemotherapeutics and CNS active drugs).7 Toxins in food (especially aflatoxin8, Viruses, bacteria, mushrooms, parasites like amoebas etc. may also infect the liver.9 According to American Gastroentorogical institutes official journal “Gastroenterology” recent survey has reported that they are 13% deaths has reported due to antibiotics and stated has “Idiosyncratic Drug Induced Liver Injury”.

Toxicity Assessment, Evaluation of Antioxidant and Hepatoprotective Activity on Cordia obliqua Fruit Extracts