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Dengue is recently reported to be the most rapidly spreading mosquito-borne viral disease and is endemic in more than 110 countries including Indonesia with two-fifths of the world population at risk. According to the data from Ministry of Health Republic Indonesia, more than 100 000 people were diagnosed with dengue fever in the 2014 and were found to be fatal in almost 1000 cases.1 An estimated 100 million cases of dengue fever and half a million cases of dengue haemorrhagic fever (DHF) occurred annually.2 The clinical presentations of DENV infections range from asymptomatic to severe illness that may lead to death if improperly managed. The symptomatic cases are categorized as undifferentiated febrile illness (UF), dengue fever (DF), dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS) and unusual dengue (UD) or expanded dengue syndrome (EDS).3

Drug of Action Cassia Alata Leaves Extract as Antiviral to Dengue Virus Serotype-2 in vitro