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Cardiovascular disease, especially coronary heart disease has been always correlated with the longterm prognosis of patients with uncontrolled hyperglycemia, especially diabetes mellitus patients. Uncontrolled hyperglycemic patients have a higher mortality risk of heart disease ranging from 2 to 4 times higher compared to non-hyperglycemic patients.1 Vascular endothelial impairment has been well observed and found as the main culprit of coronary heart disease in uncontrolled hyperglycemic patients.2-6 In uncontrolled hyperglycemic patients, endothelial dysfunction is caused by low levels and dysfunction of circulating endothelial progenitor cells (EPCs). Disruption of EPC function was found and observed in both of DM types, DM type 13 and 2. This finding proved that there is a correlation between uncontrolled hyperglycemia conditions and EPC dysfunction.4

Human Umbilical Cord Blood-derived Secretome Enhance Endothelial Progenitor Cells Migration on Hyperglycemic Conditions