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Bitter melon fruit (Momordica charantia Linn.) has extensive study as a hypoglycemic agent and it is known to treat diabetes because of its ability to lower blood sugar.1-3 Polypeptide-p and charantin work as the main compounds on bitter melon fruit that has hypoglycemic activities. However, charantin is the most widely researched compound and has been proven that it is more effective than polypeptide-p and tolbutamide (oral hypoglycemic agents) as a hypoglycemic agent in bitter melon.4

Development of Ethosome Containing Bitter Melon (Momordica charantia Linn.) Fruit Fraction and In Vitro Skin Penetration