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Cervical cancer is the fourth largest cancer in women and ranks seventh of all types of cancer in all populations in the world. Each year an estimated 528,000 new cases with death rates of up to 266,000 cases by 2012.1 Side effects of chemotherapy such as fatigue, hair loss, nausea, vomiting, diarrhea, or dry mouth are quite high. In patients with cervical cancer, there are various abnormal proteins resulting in changes of cell behavior, increased proliferation and differentiation of cells and decreased ability of cell to apoptosis. One of the proteins that play a role in anti apoptosis is Bcl-XL. Normally, these proteins work to maintain the balance of differentiation and apoptosis, but in cancer patients this protein expression was increased so that the process of cell apoptosis was inhibited and cells become immortal.2 To overcome the abnormalities of these cells, then treatment with chemotherapy, radiation or surgery is still option for cancer patients.3 Different types of existing treatments produce many harmful side effects during treatment. Therefore, to improve the efficacy of cancer treatment as well as minimize side effects can be done through the development of co-chemotherapy agents from natural materials. Development of medicines from natural ingredients is possible, some chemotherapy drugs of cervical cancer patients also come from wild plants, such as vinblastine and vincristine from tapak dara.4 One of the potential natural ingredients as a cochemotherapy agent is bandotan herb.

Co-Chemotherapeutic Effect of Ageratum conyzoides L. Chloroform Fraction and 5-Fluorouracil on Hela Cell Line