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Allergic and inflammatory diseases are the most familiar diseases all around the world. The prevalence, severity, and complexity of these diseases are getting increased rapidly. Although the many synthetic drugs have given rise to remarkable successes in the progress of novel anti-inflammatory and anti-allergic drugs, the continuous use has led to the miscellaneous and objectionable side effects. Meanwhile, the apparent usage of natural products in the management of these diseases has yet to be fully explored. For the last several thousand years, Mankind recognized that marine organisms contain substances accomplished with potent biological activity. Only recently, the serious investigation of seaweeds was started to say, only half a century ago. Currently, vital pharmacological and therapeutic products are being acquired and dynamically sought from the sea.1,2 Among the seaweeds, brown algae represent a rich source of many components like laminarins, fucoidans, and also alginic acids.3 Moreover, from the ancient time's seaweeds have been used in various fields like medicine, agriculture, etc.,4 Our present study is focused on the brown seaweed Turbinaria ornata, a widespread species belonging to Phaeophyceae, which is rich in fucoids and sulfated polysaccharides 5,6 and other components like phlorotannins, flavonoids, tannins, glycosides, etc. Turbinaria ornata has been earlier accounted for its antioxidant, anti-inflammatory, and cytotoxicity activity on murine melanoma and colon cancer.7-9 But there have not been many reports on the bioactive components responsible or which supports their biological activity. Hence, the present communication deals with the Gas chromatographyMass spectrometry (GC-MS) analysis of pet ether and chloroform extracts of marine seaweed Turbinaria ornata and molecular docking studies of identified compounds along with known synthetic standard using Schrödinger maestro for its ability to suppress inflammation and to evaluate its antidiabetic potency and further possibility for designing of potential anti-inflammatory and anti-diabetic lead from natural compounds were discussed. Phospholipase A2, human secretory phospholipase A2, and p38alpha MAP kinase are the enzymes focused in this study for the anti-inflammatory activity. These enzymes are the starting material for the inflammatory process which makes it an ideal target for the anti-inflammatory drugs. To the best of our knowledge, this is the first report on GC-MS analysis of pet ether extract of T. ornata and in-silico docking studies of its active constituents.10-12

The Identification of Bioactive Compounds from Turbinaria ornata (Turner) J. Agaradh and Computational Studies