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Diabetes mellitus (DM) is chronic metabolic disorder characterized by hyperglycemia due to subnormal functioning of insulin.1,2 Diabetic hyperglycemia if not properly regulated may lead to life threatening micro and macro vascular complications including retinopathy, neuropathy and nephropathy.3,4 Many herbal preparations specifically extracts of garlic (Allium Sativum Linn.), have been claimed useful in controlling glycemic status in Diabetes Mellitus (DM).5-10 The important sulfur compound of garlic oil, Diallyldisulphide (DADS), has been proved to be beneficial in DM.11,12 Though it is known DADS may enhance insulin action as well as may favor insulin half-life but the mechanism of DADS in regulating glucose metabolism in DM is obscure.11,13

Effect of Diallyl Disulphide (DADS) on Gluconeogenesis: A Study in Isolated Alloxan Induced Diabetic Liver