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Diabetes mellitus is a metabolic disorder characterized by derangement in carbohydrate, fat and protein metabolisms resulting from impairment in glucose homeostasis, lack of insulin secretion, and development of macro-and microvascular dysfunctions.1 Modern antidiabetic agents like sulphonylureas, thiazolidinediones, and biguanides are commercially prescribed but failed to provide a prolonged glycaemic control effect.2 The prevalence of diabetes mellitus (DM) risen dramatically in worldwide.1 DM will affect 438 million people by 2030, with 70% of cases occur in low-middle income countries. Without proper treatments, DM may cause cardiovascular disease as the major cause of morbidity and mortality.3-4 During the development of Type-2 diabetes, insulin’s ability to stimulate the cellular uptake of glucose from the blood was impaired.5-6 Hyperglycemia in diabetes mellitus can cause autooxidation of glucose, protein glycation and polyol Alpha Mangostin and Xanthone Activity on Fasting Blood Glucose, Insulin and Langerhans Islet of Langerhans in Alloxan Induced Diabetic Mice