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The use of herbal produce in the treatment of various ailments continue to receive worldwide attention by researchers as traditional medicines derived from plants have become highly important as alternative medicines in the treatment of a huge number of diseases.1-2 These plant derivatives are considered safe and more affordable for majority of the developing world. There are reports of an increase in the use of these plant produce in the developed world3 and more so with the emergence of difficult to treat bacterial infections, attention is again drawn to the use herbal alternatives. One of a long standing in use is the Garcinia kola. Garcinia kola is commonly referred to in Nigeria as “Bitter kola” due to it characteristic bitter taste. The plant is grown in the humid regions of Western and Central Africa.4-5 The tropical plant Garcinia belongs to the family Clusiaceae with origins said to be Asia, Australia, tropical and Southern Africa.6 The seeds Evaluation of Different Fractions of Garcinia kola Extracts against Multidrug Resistant Clinical Bacterial and Fungal Isolates