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Objectives: To study use, effect and adverse drug reaction (ADR) of the drugs and its impact on quality of life in patients suffering from Pemphigus vulgaris (PV). Materials and Methods: Prospective, observational study was carried out in newly diagnosed patients of PV. Baseline and follow-up data at 2, 6 and 12 weeks; disease severity (Kumar’s score), Quality of Life [Dermatology Life Quality Index (DLQI)] and ADR were recorded. Data analyzed by one-way and repeated measure ANOVA test. Results: Total 84 patients were included [Group A: Corticosteroid (n=29), Group B: Corticosteroid + Azathioprine (n=30), Group C: Corticosteroid + rituximab (n=25)]. Significant reduction ( P nd and 3 rd follow-up as compared to baseline and 1 st follow up and at 3 rd follow-up as compared 2 nd follow-up in group A, B and C. Mean difference between baseline and 3 rd follow up of Kumar’s score and DLQI was significantly higher in group C as compared to group A ( p p p p P p Conclusion: Corticosteroid with rituximab is associated with better efficacy and improvement in QOL but more expensive than corticosteroid alone / in combination with azathioprine for the treatment of Pemphigus vulgaris. Key words: Pemphigus vulgaris, Kumar’s score, Dermatology life Quality Index, Corticosteroid, Rituximab.

An Evaluation of Pharmacological Management of Pemphigus Vulgaris and its Impact on Quality of Life