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Background and Aim: The proposed work was planned to evaluate the potential protective role of aqueous Aloe vera (AV) concentrate and/or Omega-3 fatty acids (O3FAs) against GM -initiated renal toxicity in rats. Materials and Methods: Thirty female Wistar-albino rats were distributed into five equivalent groups as follows: Normal control group, GM control group, GM + AV group (200 mg/kg, p.o.), GM + O3FAs group (100 mg/kg, p.o.), GM + AV + O3FAs group. All the treatments were administered for 10 days. Renal toxicity was initiated by intraperitoneal administration of GM (80 mg/kg/day) for last 5 days of test duration. Results: Noticeable rise in the levels of serum creatinine, urea, MDA, TNF-α, TGF-β1, Fibronectin and NGAL was seen alongside a significant decrese in the levels of serum albumin, total protein content and antioxidant enzymes, SOD, GSH, catalase in GM control group. Treatment with AV or O3FAs or AV + O3FAs exhibited a considerable reduction in serum creatinine, urea, MDA, TNF-α, TGF-β1, Fibronectin and NGAL levels and a rise in the levels of serum albumin, total protein and antioxidant enzymes. Conclusion: The study concluded the importance of AV and Omgea-3 fatty acids as effective nephroprotective agents. However, the combined treatment with AV and O3FAs showed similar beneficial effects as compared to monotherapy in mitigating adverse effects of GM-initiated renal toxicity. There was no significant difference observed in monotherapy as well as combination therapy.

indian journal of pharmaceutical education

Therapeutic Interventions using Monotherapy versus Combination Therapy of Aloe vera and Omega-3 Fatty Acids on Gentamicin-initiated Renal Toxicity via Attenuation of Renal Biomarkers