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Background: Compliance is commonly and always being confused with concordance, which is a process by which a patient and health care provider make discussion and decisions together about treatment and their outcomes. General worldwide, noncompliance is a major obstacle and main challenges to the effective and efficient health care delivery. Estimation in 2003 by the World Health Organization indicates that only approximately 50% of chronic diseases patients that us living in developed countries follow their treatment as scheduled and recommended by clinicians. Objectives: To report on the status and future trends of Medications adherence. Materials: Published journal article and conference reports. Method: Data Extraction, data on area related to the patients and healthcare providers for non-adherence to the Medications were gleaned from various publications. Results and Conclusion: Low compliance to prescribed medical is a complex problem, especially for patients with a chronic illness. With increasing numbers of medications shown to do better than harm when taken as prescribed, low compliance is a growing concern, seriously undermining the benefits of current medical care. Medical non-compliance has been identified as a major public health problem that imposes a considerable financial burden upon modern health care systems.

Difficulties Facing the Patients and Extra Burden for Healthcare Providers by Non-adherence to the Medications - A Comprehensive Review