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Objective: A high performance liquid chromatographic method with ultra violet detection for simultaneous analysis of three sartans (Valsartan, Irbesartan and Telmisartan) has been developed for quality control. Method and Results: Isocratic elution on a LiChrospher C18 column (250 × 4 mm, particle size 5 μm) at the temperature 30oC with a mobile phase consisting of 10mM phosphate buffer: acetonitrile (65:35 v/v) at a flow rate 1.0 ml/min has been done. The column eluent was monitored with a UV detector at 225 nm. This allowed a rapid detection and identification as well as quantitation of the eluting peaks. Method Validation: Calibration curves for all drugs were in the range of 540 μg/ml and the linear regression coefficients were more than 0.995. Recovery rates for the sartans were in the range 96.5% to 103.1%. The limits of detection were calculated between 0.040.06 μg/ ml. Also, the limits of quantification were 0.120.16 μg/ml. Within-day and between-day coefficient of variation for all sartans at all concentrations in the range of 0.83 3.79% was calculated. Conclusion: The procedure can provide a simple, sensitive and fast method for the quality control of the three sartans in bulk and tablets.

Simultaneous Determination of Sartans by High Performance Liquid Chromatography with Ultra Violet Detection