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Asphodelus fistulosus (Asphodelaceae) has been traditionally used in the treatment of fungal and dermatomucosal infections. The present study aims to evaluate the antioxidant, antimicrobial and antiprotozoal activities of the ethanolic extract and its various fractions of seeds of the plant. Materials: Asphodelus fistulosus seeds were collected from Albaha region of Saudi Arabia. The chemicals used for the research work were purchased from Sigma Aldrich, Merck Germany and Loba India and used directly without further purification. Methods: The seeds were clean, dried and grinded to make it fine powder and extracted with 95% ethanol, ethanol and water were evaporated to get crude ethanolic extract. The crude ethanolic extract was fractionated into different fraction such as petroleum ether, dichloromethane and methanol. The extract and its various fractions were evaluated for antioxidant, antimicrobial and antiprotozoal activities. Results: The results of DPPH scavenging effect was found to be maximum for dichloromethane fraction followed by methanolic fraction and then ethanolic extract and petroleum ether fraction. The ethanolic crude extract, petroleum ether, dichloromethane and methanolic fraction were found to be active against the tested fungal strain Candida albicans. It was found that dichloromethane fraction was active against Trypanosoma cruzi and L. infantum. Discussion: The results of antioxidant study indicated that A. fistulosus contain polyphenols, proving them to be perfect sources of antioxidants. The plant showed significant antimicrobial and antiprotozoal activities. The metabolites, anthraquinones, flavonoids, terpenes and phenolic acids could be responsible for such activity of this plant. Conclusion: The results of antioxidant, antimicrobial and antiprotozoal activity of Asphodelus fistulosus supports its traditional use for the treatment of fungal and dermatomucosal infections.

In vitro Antioxidant, Antimicrobial and Antiprotozoal Activities of Ethanolic Extract and its Various Fractions from Asphodelus fistulosus Seeds