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Cisplatin is a widely used chemotherapeutic. However, it is associated with numerous adverse effects. The aim of our study was examination of cisplatin interaction with Na(+)/K(+)-ATPase (NKA, the sodium pump). This enzyme is of crucial importance for all animal cells and particularly for the kidney, which is frequently damaged during chemotherapy.

Na<sup>+</sup>/K<sup>+</sup>-ATPase inhibition by cisplatin and consequences for cisplatin nephrotoxicity