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This is a case report of a 51 year old male with marked splenomegaly, basophilia, severe thrombocytopenia, anemia and high SFKL phosphorylation downstream of Bcr-Abl, investigated for association of the e6a2 BCR-ABL fusion gene and marked basophilia. The treatment strategy implications in patients with Philadelphia positive CML are described.

IDENTIFICATION OF E6A2 BCR-ABL FUSION IN A PHILADELPHIA-POSITIVE CML WITH MARKED BASOPHILIA: IMPLICATIONS FOR TREATMENT STRATEGY