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Several studies suggest that changes in estrogens and androgens during menopause play a role in the regulation of leptin production. Some authors present hypothesis that sex hormone replacement therapy can modulate leptin levels but up to date evidence shows that the influence of endogenous estrogens, androgens levels and sex hormone therapy on leptin concentration remains uncertain.

THE INFLUENCE OF ESTRADIOLE AND TIBOLONE ADMINISTRATION ON LEPTIN LEVELS IN WOMEN WITH SURGICALLY INDUCED MENOPAUSE