English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objectives: The primary cause of the metabolic syndrome appears to be obesity that is associated with a low-grade inflammatory state resulting from insulin resistance in both adult and pediatric populations. Heat shock protein 70, S100A12 and matrix Gla protein are involved in chronic inflammatory diseases. We aimed to evaluate the association between these markers and childhood obesity and metabolic syndrome. Materials and Methods: This study was performed with 45 obese children aged 10-15 years and 47 children with metabolic syndrome aged 10-15 years. Serum heat shock protein 70, S100A12 and matrix Gla protein levels were measured by using ELISA method. Results: Serum matrix Gla protein and S100A12 levels in obese subjects were significantly higher than metabolic syndrome groups (p<0.05). However no significant differences were observed in serum high sensitivity Creactive protein (p=0.288) and heat shock protein 70 (p=0.960) levels between metabolic syndrome and obese subjects. There was a significant positive correlation between serum S100A12, matrix Gla protein and heat shock protein 70 levels in both groups. Conclusions: Our findings showed a significant association between heat shock protein 70, S100A12, matrix Gla protein, and obesity and metabolic syndrome. Obesity may be involved in increased risk of developing metabolic syndrome. It might be useful to focus on the roles of these proteins in obesity in accordance with the prevention of the development of metabolic syndrome and other metabolic disorders like diabetes.

Serum Heat Shock Protein 70, S100A12 and Matrix Gla Protein in Childhood Obesity and Metabolic Syndrome