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OBJECTIVE: The purpose of this work is measure tests using butyrylthiocholine as a substract and get the spectrofotometric results for dispersion level of Cholinesterase in people who is working in the pharmaceutical and agriculture sector, were chronicly affected bypesticide or patiences who are suspected to be poisoned by pesticide, who applied for the Consumer Safety Health Effects Research Laboratories RSHMB biological material lab, Ankara during the period 2008-2010.METHODS: The blood samples were analyzed by the biological materials laboratory. The plasmas Cholinesterase levels were measured with the kits Cholinesterase, butyrylthiocholine kinetic, Spınreact between 01.01.2008 - 17.07.2010; after 17.07.2010 Cholinesterase, butyrylthiocholine substrate, (Quimica clinica aplıcada S.A.) The plazmas were seperated from the blood samples and preoperate on them with the spectrofotometric methods under the room temperature of 405nm and Cholinesterase, levels measured by quantitative analysed methodRESULTS: Evidence: In this research 1136 people whose Cholinesterase levels tested; applied to our center because of pestisit toxication. 367 (32,3 %) were the ones who works for the pharmaceutical sector and intended to be under control, 769 (67,7%) were the ones prediagnoised as poisoned. It has been detected that 222 (28,9%) of them were in safe serum Cholinesterase measurement range. 119 (53,6 %) of these people were women and majority of them 56 (25,2 %) is in 10-19 age group. 347 (94,6 %) people who is working either in the pharmaceutical or agriculture sector were in normal range and just 20 (5,4 %) of them were in the toxicty range. The intoxicated workers were in the age group of 30-39.CONCLUSION: The Cholinesterase level of the persons, who sprayed or werepoisoned by insecticide containing organophosphate, is of utmost importance.In our research 547 patiente (71,1 %) and 347 workers (94,6%) were in normal range of cholinesterase level. This results shows that the patiente who pre diagnosed as toxicated should be well examined. Also to determine the workers and examined thier cholinesterase levels who is from pharmaceutical sector and Works with organophosphore insecticide; is very important in economically and workload basis

Determination of cholinesterase levels of the employees working at the pharmaceutical sector and the patients suspected of being poisoned