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We investigated the individual and combined effects of magnesium sulphate, which is an N-Methyl-D aspartate receptor antagonist (NMDA), and z-LEHD-FMK, which is a caspase 9 inhibitor, on the genesis of secondary injury in a rat spinal cord injury model. We aimed to minimize the effects of secondary injury in spinal cord trauma by choosing these two agents which served to block the two major mechanisms of cell loss, apoptosis and necrosis.

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EFFECTS OF COMBINED AND INDIVIDUAL USE OF NMDA RECEPTOR ANTAGONIST MAGNESIUM SULPHATE AND CASPASE-9 INHIBITOR z-LEDH-fmk IN EXPERIMENTAL SPINAL CORD INJURY