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METHODS In total, 28 outpatients with HNC (24 male and 4 female) who were admitted to the Gazi University, Department of Radiation Oncology, between October 2008 and November 2009 were retrospectively evaluated. The mean age of the patients was 18–76 years. All the patients were histopathologically diagnosed with squamous cell carcinoma. Of the 28 patients who were included in the radiotherapy (RT) program, five were postoperatively included and 23 were included according to organ protection protocols. Eighteen patients prophylactically received oral powdered L-glutamine (Glutamine ResourceR, Nestle) starting from the first day of RT at a dose of 30 g/day (10 g each at 8-h intervals by mixing with water or fruit juice). For these patients, glutamine supplementation was continued until the completion of RT. Ten patients did not receive any supplementation product. At the initiation of RT, height and weight were measured for all the patients. The grade of oral mucositis was evaluated using the “Radiation Therapy Oncology Group (RTOG)” scoring system. During RT, changes in the weight of patients were routinely evaluated, whereas oral mucositis scoring was performed every week. At the beginning, during, and at the end of the therapy, serum IL-1 beta, IL-6, and TNF-alpha levels were measured, in addition to performing routine blood tests.

türk onkoloji dergisi

The Effect of Using Oral Glutamine on the Side Effect of Mucositis in Patients with Head and Neck Cancer Who Are Receiving Chemoradiotherapy: Retrospective Evaluation with Clinical and Immunological Parameters