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Objective: The susceptibility of plasma adrenocorticotropic hormone (ACTH) to enzymatic degradation has limited the stability of ACTH. Many non-routine tests require the collection of blood on special proteinase inhibitor cocktails to preserve the integrity of the sample. This may provide benefits in sample collection and routine clinical practice. This study examined if a proteinase inhibitor, aprotinin, mixed with blood at the time of collection, would change the stability of ACTH in plasma at various temperatures for several hours and days using immunoassay.

turkish journal of biochemistry

The effect of temperature and aprotinin on the preanalytical stability of Adrenocorticotrophic hormone / Sıcaklığın ve aprotininin Adrenokortikotropik hormonun preanalitik stabilitesine etkisi