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Purpose: In the present study, we aimed to investigate the specific side-effects and effects of adjuvant agents used intrathecally on the properties of spinal anesthesia. Materials and methods: 100 cases were randomly divided into 5 groups of 20 cases. Saline group: 15 mg 0.5% hyperbaric bupivacaine + 0.5 mL saline, Bupivacaine Group: 17.5 mg 0.5% hyperbaric bupivacaine, Fentanyl Group: 15 mg 0.5% hyperbaric bupivacaine + 25 µg fentanyl, Sufentanyl Group: 15mg 0.5% hyperbaric bupivacaine + 2,5 µg sufentanyl, Neostigmine Group: 15 mg 0.5% hyperbaric bupivacaine + 250 µg neostigmine, The volume of the intrathecally administered drug was 3.5 mL in all groups. After spinal anesthesia, sensory block level was measured by pin-prick test every 5 minutes and motor block level was measured by Bromage scoring. Sensory and motor block durations of the groups were recorded. The side effects that occurred were recorded. Results: Effects of different adjuvant agents on the properties of spinal anesthesia differed. Fentanyl statistically significantly prolonged sensory block durations compared with other groups. Fentanyl and sufentanyl statistically significantly raised the 20th-minute sensory block level compared with other groups. In the bupivacaine group, the 5th-minute motor block level was detected to be statistically significantly higher than other groups. Specific side-effects occurred for each adjuvant agent. Occurrence of hypotension in the saline group was statistically significantly higher compared with other groups. Conclusion: Effects of different adjuvant agents on the properties of spinal anesthesia are different and they cause specific side-effects. Fentanyl prolongs sensory block level and duration. As the local anesthetic dose increases, the increase in the motor block level accelerates and as the quality of anesthesia decreases, occurrence of hypotension increases. Pam Med J 2013;6(2):44-51

Fentanyl, Sufentanil and Neostigmine's effects on charecteristics of the spinal anesthesia