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Brucellosis is one of the most common zoonotic diseases in the world, and it is particularly endemic in Mediterranean countries, Arabian Peninsula, India, Africa and South America (1). It generally manifests an acute febrile disease, but in some cases, it can show a chronic progression with life-threatening complications. According to World Health Organization (WHO), Brucella melitensis is responsible for the majority of the human cases, and 500,000 new patients are reported every year around the world (2).

Investigation of Synergistic, Additive and Antagonist Effect of Antimicrobial Combinations Used for Brucella spp., with E-test Combination Method