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During the gastrointestinal endoscopy procedure for diagnosis or treatment, sedation is performed in many centers. During the esophagogastroduodenoscopy procedure, the feeling of tingling and suffocation is frequently encountered, and the patients feel uncomfortable because of the abdominal pain, swelling, and embarrassment (1). Colonoscopy sedation reduces the discomfort and anxiety of patients, it also provides an environment for the endoscopist to increase success and comfort during the procedure (2). Today, It is still a matter of debate as to which medicines are to be used for sedation especially during time-consuming procedures such as colonoscopy and endoscopic retrograde cholangiography, and which combination is less risky or cost-effective (3).

Comparison of Ketamine-Midazolam-Propofol Combination and Fentanyl-Midazolam-Propofol Combination for Sedation in Colonoscopy