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Lung cancer is the most common cancer type in the World currently. According to Globocan 2012 data published by International Cancer Agency (IARC) 14.067.894 cancer cases were diagnosed worldwide and lung cancer formed 13% of those cases (1.824.701) (1). In Turkey, according to data by T.R. Ministry of Health, Administration of Public Health, Department of Cancer, lung cancer incidence is at 1st order in males and at 4 th order in females (2). Lung cancer is divided into two groups histologically: non small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) (3, 4). SCLC is the most aggressive with highest mortality rate and accounts 12-14% of all lung cancer cases (5). NSCLC is the most commonly encountered lung cancer type and constitutes approximately 80-83% of all cases diagnosed with lung cancer. NSCLC also divided to histological subtypes such as adenocarcinoma, squamous cell carcinoma, large-cell carcinoma and broncoalveolar carcinoma. Among those subtypes, adenocarcinoma is the most common (6). Formation of lung cancer is related with various environmental and genetic factors (7). Although patients diagnosed with lung cancer at similar stages and histological subtypes, they can have great differences in their prognosis. Those differences may be related with increase or decrease of some proteins (ex. proteins counterpart in coagulation) which are not directly related with cancer formation (8).

Beta-Fibrinogen 455 G/A and Angiotensin Converting Enzyme Ins/Del Polymorphisms In Patients With Lung Cancer