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Super-oxidized water (SOW) is a relatively new formulated pH-neutral solution that has a potent disinfectant activity (1). SOW does not cause harmful effect on the human tissues and used for various conditions like wound, skin infections, ulcers and diabetic foot (2,3). The other forms of this formulation were not neutral pH and has a strong acid aqueous ingredient and theoretically may lead to toxic and negative effect on the tissue and subcellular level (4). SOW is generated by exerting electrical current on salty water and conduct electrochemically in aqueous solutions from water and sodium chloride. Water is reduced to oxygen, ozone and other reactive species however, the major ingredient formed during this process is hypochlorite and hypochlorous. On marketing, there are a variety of compounds that have different concentrations and pH values (5). On literature search, it was reported and confirmed by several studies that SOW has a potent antimicrobial activity including viruses and bacteria (6). Although SOW is used mainly for hospital wall’s surfaces and metal health’s equipment, many published data investigated its effect on external surface of body such as in diabetic foot ulcers, burn wounds and skin infections (7). However, there are limited data about the use of SOW in intraabdominal organs or within the integrity of body system. Two studies investigated the effect of super-oxidized solutions on the perforated appendicitis with intraabdominal use and found beneficial effects. However, these molecules were in strong acid component. The tuba-ovarian abscess and pelvic peritonitis are common complications of pelvic inflammatory disease. During the surgery of these conditions, abscess drainage is maintained with addition of normal saline irrigation of peritoneal cavity which is in fact has no microbicidal activity. Therefore, it will be rational to use a potent pHneutral and non-toxic agent like SOW during these operations. As far as we know, there is no study that evaluated the effect, toxicity and complications of SOW on uterine and ovary tissue during direct intraabdominal infusion. Aim of this study is to conduct an experimental rat study to investigate the macro and microscopic findings in uterine and ovary tissues following the ABSTRACT

The effect of super-oxidized water on the tissues of uterus and ovary: An experimental rat study