English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Carbon tetrachloride (CCL4) is a transparent, nonflammable toxic chemical which may quickly evaporate from its liquid form (1). Experimental or unintended exposure to CCL4 causes serious hazards to organisms. It is a cytotoxic xenobiotic. Cellular damage due to CCL4 is caused by augmented lipid peroxidation. CCL4 transforms into CCL3 which is a free radical (2). Main outcome of CCL4 exposure is hepatotoxicity. Experimental studies reveal that CCL4 causes hepatic fatty degeneration, mononuclear cell infiltration, fibrosis, degeneration in hepatocytes, cirrhosis and cancer (3). Since liver degeneration due to CCL4 resembles cirrhosis advance in humans, CCL4 is widely used as a chemical agent in experimental studies in rodents. Oxidative stress is an important counterpart in this liver toxicity caused by CCL4. Various synthetic and natural compounds mainly from plants were tested against CCL4 toxicity (4). Crocus sativus is a member of Iridaceae plant family. It is known as saffron. It is widespread in Turkey and Iran and used as food and for cosmetic purposes. In addition, it is used in ethnomedicine as anti-spasmodic, aphrodisiac, anti-convulsant, stomachic and in treatment of diseases such as dysentery, cholera, depression and insomnia. Scientific studies on this plant and its active ingredients revealed that it has antidepressant, anti-convulsant, anti-inflammatory, antidiabetic and anti-tumoral activity (5-8). Saffron and its ingredients; safranal, crocin and crocetin are proven to exert anti-oxidant activity in many studies (9-14).

easterns journal of medicine/eastern journal of medicine

Effect of safran, safranal and crocin which are active ingredients of Saffron (Crocus) on erythrocyte fragility and hematological parameters in carbon tetrachloride intoxicated rats