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Although the expression of both maspin and GLUT-1 have been shown to increase in many human cancers such as endometrioid carcinoma, their long-term prognostic relevance has not yet been established. The aim of our study is to investigate the overexpression of maspin and GLUT-1 in malignant endometrial tissues, to evaluate its role in the neoplastic progression to an endometrioid carcinoma, to establish prognostic clinical parameters and to predict survival. METHODS: The sample participants comprised of 68 patients with endometrioid adenocarcinoma and 68 patients with benign endometrial tissues. The immunostaining pattern for maspin was accepted as nuclear. Nuclear staining of tumoral tissues and normal endometrial tissues were scored according to cell ratios as follows: negative staining <25%; positive staining 25% 100%. The linear staining pattern for GLUT-1 was accepted as membranous. The percentage of positively stained tumor cells in the tissue samples were semiquantitatively determined with negative staining <5% and positive staining 5% 100%. The follow-up period ranged from 6 to 60 months with a mean of 53,8 months. Primary end points were determined as all-cause

Maspin and GLUT-1 expression in endometrial carcinomas and prognostic relevance