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We aimed to create subgroups in terms of tumor size, number and previous recurrence status in intermediate-risk non-muscle invasive bladder cancer (NMIBC) and evaluate the predictive roles of these parameters in determining recurrence. MATERIAL and METHODS: 99 patients who were treated and followed up between January 2009 and December 2015 with the diagnosis of intermediate-risk NMIBC were retrospectively analyzed. Group I consisted of primary, single, Ta grade, low grade, larger than 3 cm (> 3 cm) tumors; Group II consisted of primary, Ta grade, low grade, smaller than 3 cm (<3 cm), multiple tumors and Group III consisted of recurrence of previous low-risk tumors. Three groups were compared in terms of clinical, pathological findings and recurrence in follow-up. RESULTS: Mean age of patients was 65.73±12.21. Among them, 41 (41.4%) patients had recurrence in median 48 (15-84) monthly follow-up. Recurrence rate in Group III (58.8%) was significantly higher than Group I (29.6%) and Group II (34.2%) (p = 0.039). The predicted recurrence-free survival (36.1 months) in Group III was significantly lower than Group I (54.8 months) and Group II (61.2 months) (p=0.01 and p=0.003, respectively). In univariate analysis, the presence of previous recurrence, tumor size, number and CUETO score Orijinal Çalışma 178 Adress for correspondence: İsmail Selvi, Karabük Üniversitesi Eğitim ve Araştırma Hastanesi, Üroloji Kliniği 78200 Merkez / Karabük – Türkiye e-mail: ismselvi33@hotmail.com Available at www.actaoncologicaturcica.com Copyright ©Ankara Onkoloji Hastanesi were reported as independent predictive factors for recurrence. In multivariate analysis, only the presence of previous recurrence was found to be significant. DISCUSSION and CONCLUSION: The subgroup analysis of intermediate-risk NMIBC may be helpful in determining tumor treatment and follow-up protocols.We state that new tumor recurrences may be higher in intermediate-risk NMIBC with previous recurrence history.

Is subgroup analysis of intermediate-risk non-muscle invasive bladder cancer important in predicting recurrence?