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Negative expression of BRCA1 and BRCA2 was found in 12.5% and 22.5% of benign tumors, 25.0% and 33.3% of borderline tumors, and 36.5% and 40.4% of carcinomas, respectively. Expression of PARP1 was detected in 22.5% of benign tumors, 58.3% of borderline tumors, and 69.2% of carcinomas. Negative expression of BRCA1 with BRCA2 correlated with the expression of PARP1. Conclusion Negative expression of BRCA1 with BRCA2 and PARP1 expression may play an important role in the development of ovarian tumor.

Immunohisochemical study of BRCA1, BRCA2, and poly (ADP-ribose) polymerase-1 in ovarian tumors