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Histopathological and immunohistochemical studies were conducted to elucidate the characteristics of nevus cells that accumulate in intramucosal nevi in the oral mucosa, primarily focusing on the maturation and origin on these cells. Twelve cases (5 men, 7 women ; mean age : 29.8 years) of intramucosal nevi were examined, with the most frequent site being in the gingiva. Macroscopically, Miescher's nevi were seen more frequently than Unna's nevi. Intramucosal nevi were characterized by a proliferation of nevus cells only within the underlying connective tissue, exhibiting maturation but not neuroid differentiation. From the immunohistochemical analysis of the nevus cells, staining for S100, Melan-A, and MITF was stronger in A-type cells than in deeper B-type cells, although B-type cells along the edge of the nevus cell nest exhibited moderate positive for S100, Melan-A, and MITF. Positive cytoplasmic expression of c-Kit was scattered in B-type cells deep within the lesion and in mast cells surrounding the blood vessels around the nevus cell nest. These results and a review of the literature suggest that nevus cell formation begins with the proliferation of melanocytes and their migration into the submucosa with a concomitant loss of cell adhesion. Nevus cells exhibited decreased melanocytic development with the depth of the lesion. However, along the edge of the lesion, B-type cells exhibited melanocytic but not neuroid differentiation. Thus, maturation of nevus cells could be a form of adaptation to the surrounding environment.

international journal of oral-medical sciences/ijoms

Histopathological and Immunohistochemical Studies of Intramucosal Nevus in the Oral Mucosa: With Special Reference to "Maturation" and "Origin" of the Nevus Cells