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Leiomyosarcoma is an uncommon malignant mesenchymal neoplasm that exhibits smooth muscle differentiation. Rare occurrence of this neoplasm in the oral cavity is attributed to the paucity of smooth muscle in this location. Leiomyosarcomas of the oral cavity are associated with aggressive clinical behavior and low survival. To the best of our knowledge, only 69 cases of leiomyosarcoma involving the oral cavity have been reported in the English language literature, with 44 cases manifesting intraosseously in the maxilla and mandible. The purpose of this report is to present an additional case of intraosseous mandibular leiomyosarcoma in a 15-year-old girl and to summarize the data of isolated case reports of primary mandibular leiomyosarcomas that have been published in the English language literature during the past 75 years.

Leiomyosarcoma of the Mandible in a 15-year-old Girl: A Case Report and a Brief Literature Review of Mandibular Leiomyosarcomas