English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Our previous studies have shown that antigen-specific mucosal immune responses are induced in CD4 gene disrupted (CD4-/-) mice after oral immunization with tetanus toxoid (TT) plus cholera toxin (CT) as mucosal adjuvant. Furthermore, CD4-CD8- T cells showed significant levels of antigen-specific proliferative responses in both mucosal and systemic lymphoid tissues. In this study, we further elucidated nature of antigen-specific CD4-CD8- T cells in those immunized mice. Analysis of TT-specific T cell responses showed that CD4-CD8-, but not CD8+, T cells in Peyer's patches (PP) produced Th2-type (IL-4 and IL-5) cytokines after oral immunization with TT plus CT. Furthermore, CD4-CD8- T cells isolated from PP of immunized CD4-/- mice when added to B cell cultures induced increased number of TT-specific IgG and IgA producing cells. These results suggest that CD4-CD8- T cells in PP of CD4-/- mice are capable of inducing antigen-specific T helper cytokines and provide help for mucosal IgA antibody responses in the absence of CD4+ T cells.

Mucosal Immunity in CD4-Deficient Mice: CD4-CD8- T cells Provide Help for Mucosal IgA Antibodies