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Purpose : Relapse is clinical problems in orthodontic treatment, and the cause is not clear. The release of accumulated mechanical tension on the collagen fibers in the periodontal ligament(PDL)is thought to be one of the factors associated with relapse. Daidzein is extracted from soybeans and which is involved in collagen turnover of skin. However, little is known about the effects of daidzein on the collagen metabolism in human PDL(hPDL) cells. Then, we investigated the effects of daidzein on the release and the expression of collagen type I(COL-I)and matrix metalloproteinase(MMP)1 in stretched hPDL cells. Materials and Methods: hPDL cells were subjected to tension (10%)using cell stretchchambers, after 12 hours, the cells were treated daidzein(50 g/ml)for 48 h. The release and gene expression of COL-I and MMP1 in stretched hPDL cells treated with daidzein were examined using enzyme-linked immunosorbent assays and a real-time PCR. Results : The daidzein+TF group increased the gene expression of COL-I and MMP1 in comparison to the corresponding TF group in a time-dependent manner for up to 24 h . The release of COL-I and MMP1 from the daidzein+TF group were increased in comparison to the corresponding TF group in a time-dependent manner for up to 48 h. The relative COL-I and MMP1 mRNA expression in treatment of daidzein were significantly higher than in the not treatment of daidzein group. Conclusion : The results in this study showed that daidzein regulates the collagen metabolism in stretched hPDL cells via the release and expression of COL-I and MMP1.

international journal of oral-medical sciences/ijoms

&lt;b&gt;Effects of Daidzein on the Production of Type I Collagen and Matrix Metalloproteinase1 by Stretched Human Periodontal Ligament Cells &lt;/b&gt;