Varenicline-induced manic episode

Varenicline is a novel antismoking agent that reduces cravings and blocks pleasure of nicotine by serving as a partial agonist to the nicotinic receptor. Varenicline has been associated with some important psychiatric adverse effects in patients with psychiatric history. However, varenicline related manic episode has not been reported so far in the literature in patients with no psychiatric history. Here we report a manic episode case with psychotic features developed in an individual on varenicline with no personal and family psychiatric history.