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The objective of this study was to evaluate the dose-response effect of a chitooligosaccharide (COS) produced by Universidade Estadual de Londrina over performance, diarrhea episodes, visceral characteristics and morphometry. A total of 72 Pen Ar Lan® piglets were weaned at 23 days and 7.51 ± 1.35 kg of BW. The treatment was a basic diet plus inclusion of 0, 50, 100, or 150 ppm of COS (100 mg/kg). For the visceral and morphometric evaluation, 24 animals were slaughtered at 31 days of age with 11.01 ± 1.25 kg of BW. No regression effect over the performance or diarrhea prevalence was observed. Higher doses of COS led to higher absolute values for large intestine weight, villus height in the jejunum and crypt depth in the jejunum and ileum; the villus/crypt ratio in the ileum was higher until the level of 100 ppm COS. More lesions were observed in the intestinal epithelium along with a higher total number of lymphocytes and eosinophils in the duodenum. High numbers of eosinophils were observed in the ileum when a higher level of COS was used. In general, increasing levels of COS led to better intestinal morphometry and activated somatic cells in the lamina propria of the piglet intestine; however, no influence was observed in the productive performance of these animals. Considering all studied parameters, the COS level of 100 ppm was the most promising under these experimental conditions

Chitooligosaccharide for piglets: effects on performance, viscera and intestinal morphometry