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The objective of this study was to verify probiotics and monensin effects on metabolic parameters in weaning lambs. In the experiment 1, thirty lambs divided in three groups were fed during 6 weeks. The lambs were enrolled in one of the following treatments: GC1: as a control, GB1: Bacillus cereus var. toyoi (1x106 spores/g) and GS1: Saccharomyces boulardii (1x106 viable cells/g). In the experiment 2, thirty lambs divided in three groups were fed during 8 weeks. The treatments consisted in GC2: as a control, GM2: monensin (500g/t) and GS2: Saccharomyces boulardii (1x106viable cells/g). In both experiments blood samples were collected weekly aiming to measure metabolic parameters as glucose, triacylglycerol (TAG), cholesterol, albumin, urea, aspartate amino transferase (AST), creatinine kinase (CK) and gamma glutamil transferase (GGT). The results from experiment 1 demonstrated that GS1 had greater (P<0.05) concentrations of albumin and urea during the adaptation period. In the postadaption period the GC1 demonstrated increased (P<0.05) concentrations of cholesterol, albumin and AST activity, in contrast, reduced (P<0.05) concentrations of glucose, urea and CK in comparison to GS1. However, during experiment two throughout the adaptation period the GS2 had greater (P<0.05) concentrations for albumin and urea. The GM2 had greater (P<0.05) concentrations for TAG and lower (P<0.05) for glucose and CK activity. During the post-adaption period the GS2 showed the lowest (P<0.05) concentrations for cholesterol and GGT activity, GC2 had greater (P<0.05) levels of albumin and AST activity as well as lower concentrations for urea. The GM2 had greater levels for GGT activity and lower levels for CK activity. Therefore, it is concluded that protein metabolism in lambs has better performance when Saccharomyces boulardii is added in the ration during the adaptation period. However, during post-adaptation period, monensin is more beneficial for the protein metabolism, once it does not interfere in the muscles catabolism.O objetivo do estudo foi verificar o efeito de probióticos e monensina sobre parâmetros metabólicos de cordeiros desmamados. No primeiro experimento foram utilizados 30 cordeiros, alimentados durante 6 semanas, de acordo com os seguintes tratamentos. GC1: Controle (sem aditivo), GB1: Bacillus cereus var. toyoi (1x106 esporos/g) e GS1: Saccharomyces boulardii (1x106 células viáveis/g). No segundo experimento foram utilizados 30 cordeiros, alimentados durante 8 semanas divididos em três tratamentos: GC2: Controle (sem aditivo), GM2: Monensina sódica (500g/t) e o GS2: Saccharomyces boulardii (1x106 células viáveis/gr). Semanalmente foram coletas amostras de sangue. Em ambos os experimentos foram avaliados: glucose, triacilglicerídeos (TAG), colesterol, albumina, ureia, aspartato amino transferase (AST), creatinina quinase (CK) e gama glutamil transferase (GGT). O GS1 obteve maiores concentrações de albumina e ureia (P<0,01), quando comparado aos demais grupos, no período adaptativo. O GC1 demonstrou maiores concentrações de colesterol, albumina e atividade de AST (P<0,05), e menores de glucose, ureia e atividade de CK (P<0,05), quando comparadas ao GS1, no período pós-adaptativo. No experimento dois durante o período adaptativo o GS2 obteve maiores concentrações de albumina e ureia (P<0,01), quando comparado aos demais. O GM2 obteve maiores concentrações de TAG (P<0,01) e menores de glucose e atividade de CK (P<0,05), quando comparado aos demais, no período adaptativo. O GS2 obteve menores concentrações de colesterol e atividade de GGT (P<0,05), quando comparado com os demais, no período pós-adaptativo. O GC2 obteve maiores concentração de albumina e atividade de AST (P<0,01), e menores de ureia (P<0,05), quando comparados com os demais, no período pós-adaptativo. O GM2 obteve maior atividade de GGT (P<0,05) e menor atividade de CK (P<0,05), quando comparado com os demais, no período pós-adaptativo. O metabolismo proteico dos cordeiros demonstrou melhor desempenho no período pré-adaptação com Saccharomyces boulardii, já no período pós-adaptativo a monensina apresentou menor catabolismo muscular

Avaliação metabólica do uso de probiótico ou monensina em cordeiros mantidos em semi-confinamento