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O verapamil e outros bloqueadores dos canais de calcio sao usados como antihipertensivos e antiarritmicos tratamentos prolongados ou por toda a vida, podendo ser indicados em gestantes. Foi estudado o efeito do bloqueador dos canais de calcio sobre o germe dental, tempo de erupcao dentaria de filhotes nascidos de maes tratadas e mineralizacao ossea nas maes. As femeas tratadas foram divididas em dois grupos: o primeiro recebeu verapamil na dose de 2,4 mg/rato/dia e o segundo, 24 mg/rato/dia. Os animais foram divididas em dois subgrupos: o primeiro recebeu a droga durante 10 semanas: 7 semanas antes do acasalamento e 3 semanas durante a gestacao realizando-se a operacao cesariana ao 21o dia; o outro foi tratado como o primeiro, porem os filhotes nasceram de parto natural e o tratamento das maes foi continuado por 15 dias. Foram determinados os niveis plasmaticos de calcio e fosfato de maes e filhotes. As cabecas dos filhotes foram seccionadas para histologia dos germes dentarios e determinados os pesos umido e seco do osso femoral das maes. Os resultados mostraram que a droga, na dose mais elevada, diminuiu os niveis sericos de calcio e fosfato nas maes, enquanto que nos filhotes, os valores foram significativamente mais baixos em comparacao com as maes. O verapamil causou aumento da mineralizacao ossea nas maes durante a gestacao, mas nao apos o parto. Um aumento da calcificacao dos germes dentarios dos filhotes nao pode ser demonstrada, porem na dose mais elevada, o verapamil causou retardo significativo na erupcao dentaria. Abstract Verapamil and other calcium blocker drugs are used as antihypertensive and antiarrhythmic in long term treatments and appropriate to be prescribed for pregnant women. It was studied in rats the effects of verapamil on dental germ calcification, the time of dental eruption in offspring born from treated mothers and on mothers bone mineralization. The rats were divided in two groups: one received verapamil in doses of 2.4 mg/rat/day and the other, 24 mg/rat/day. The animals were divided in two subgroups: one was treated during 10 weeks: 7 before mating and 3 during pregnancy, cesarean surgery performed on the 21st day; the other was treated in the same way but the offspring were born by natural delivery and the mothers treatment continued for 15 days. Plasma calcium and phosphate were assayed in mothers and offspring. The offsprings heads were isolated to histology of dental germs and determined mothers femoral bone fresh and dry weights. Results show that the higher dose verapamil lowered mothers plasmatic calcium and phosphate while a significant lower values were observed in offspring as compared to their mothers. Verapamil increased mothers femoral bone mineralization during mineralization but not after delivery. An increased calcium deposition of dental germ could not be demonstrated but verapamil significantly delayed newborns dental eruption.

EFFECTS OF CALCIUM CHANNELBLOCKER VERAPAMIL ON BONE AND DENTAL GERM IN RATS