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Cytotoxic CD8 T lymphocytes are the major cells of the immune response to viral infection and tumor rejection. Differentiated CTLs have a large number of modified lysosomes including perforin and granzyme B. Mammalian ste-20 like kinase Mst1 is abundantly expressed on lymphocytes and plays important roles during apoptosis, proliferation, cell polarity, and migration. Here, we report the new role of Mst1 for cytotoxic T-cell responses and tumor reduction. Mst1 cytotoxic T cells also showed enhanced T-bet expression associated with elevated expression levels of IFNγ and granzyme B. In addition, Mst1 cytotoxic T cells suppressed tumor growth and prolonged overall survival of tumor bearing mice in vivo. Thus, Mst1 is a potential therapeutic target for tumor immunotherapy.

Enhanced cytotoxic T cell function and suppression of tumor development by Mst1 deficiency